PHARMACOKINETICS OF ABBOTT CYCLOSPORINE FOLLOWING LIVER TRANSPLANT

$0M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

Investigators

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Abstract

Cyclosporine immunosuppression is a mainstay of organ transplantation. Outpatient prescriptions for cyclosporine can approach $1000 a month. Generic cyclosporine has been shown to be bioequivalent to the brand name Neoral in normal subjects, kidney transplant recipients at least 6 months after transplant and in newly transplanted kidney recipients. This protocol is the first attempt to show bioequivalence of generic cyclosporine and Neoral in liver transplant recipients.

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