PHASE I TRIAL OF SINGLE DOSE J 107088 IN PATIENTS WITH ADVANCED CANCERS

$28,104M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

Investigators

Linked publications & trials

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Abstract

This is a first-in-human phase I trial of a novel antineoplastic agent, J-107088, a topoisomerase inhibitor in patients with advanced, refractory malignancies. The primary objectives are 1) to define the maximum tolerated dose (MTD) of J-107088 when administered as a single dose every 21 to 28 days, 2) to evaluate the pharmacokinetics profile to J-107088 and its metabolites, and 3) to determine the toxicity profile of J-107088. Patients will be enrolled on successively higher dose levels until an MTD is reached.

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