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INSULIN AS REGULATOR OF SKELETAL MUSCLE BLOOD FLOW

$28,104M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

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Abstract

Recent evidence suggests that insulin increases muscle glucose utilization by increasing blood flow through recruitment of new blood vessels. We hypothesize that insulin's action as a vasodilator in this fashion is blunted in the obese patient or the patient with Type 2 DM. We will examine total forearm blood flow using plethysmography and Doppler ultrasound and flow distribution using microbubble contrast ultrasound in 8 lean, 8 obese, and 8 Type 2 DM subjects before and after local insulin infusion.

View original record on NIH RePORTER →