GENE THERAPY (AD OC TK) FOR TREATMENT OF PROSTATE CANCER

$28,104M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

Investigators

Linked publications & trials

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Abstract

A phase I study of a replication-defective adenovirus containing an osteocalcin promoter and thymidine kinase gene (Ad-OC-TK) into lesions in men with either locally recurrent prostate cancer following definitive surgical removal or patients with non-solid organ metastatic prostate cancer (bone and lymphatic). The primary objective of this phase I study will be to evaluate the safety of this therapy. A secondary objective will be to evaluate the efficacy of this approach.

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