GH RECEPTOR ANTAGONIST B2036-PEG AND GH SECRETION

$0M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

Investigators

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Abstract

The decline in GH secretion with aging is mediated by a reduced hypothalamic stimulation of somatotrophs. Blockade of GH feedback with a GH receptor antagonist (opening the negative feedback loop) will augment GH secretion more in young than in older adults.

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