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FEEDBACK ACTIONS OF CORTISOL ON ACTH RELEASE IN MEN

$0M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

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Abstract

The nature of the feedback regulation of ACTH release by cortisol will be tested in normal men. Women are being studied similarly in a collaborating GCRC. We will administer a potent inhibitor of adrenal steroidogenesis before and then with concomitant pulsatile or continuous intravenous delivery of cortisol over 24hrs. This will tell us if a pulsatile cortisol signal shuts off ACTH secretion more efficiently.

View original record on NIH RePORTER →