FEEDBACK &METABOLIC CLEARANCE OF IGF-1 AND SEX STEROID

$0M01FY2000RRNIH

University Of Virginia Charlottesville, Charlottesville VA

Investigators

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Abstract

This study in older men and women tests two hypotheses: (i) the insulin-like growth factor, IGF, suppresses growth hormone (GH) less in the presence of sex-steroid hormones than in their absence; and (ii) sex-steroid hormones increase the metabolic clearance rate of IGF-I, but not GH.

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