DISRUPTION OF HUMAN HEMATOPOIESIS BY HIV 1

$27,361M01FY2000RRNIH

Scripps Research Institute, La Jolla CA

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Abstract

The specific goals of this study are: a) to investigate whether the cellular tropic and cytopathic characteristics of distinct HIV-1 isolates allows for infection and death of hematopoietic stem/progenitor cells; and b) to investigate whether HIV-1 infection reduces the "stem cell capacity" of the putative CD34++CD38+/- stem cells engrafted NOD/SCID mice transplanted with a human thymus. GCRC Normal Blood Donors (SPID 0075) were essential to this project.

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