PEG IFN VS ROFERON A FOR CHRONIC HEPATITIS C WITH CIRRHOSIS

$27,361M01FY2000RRNIH

Scripps Research Institute, La Jolla CA

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Abstract

This study compares the safety and efficacy of 2 doses (90 and 180 micrograms) of PEG-interferon alpha-2a given once a week with a standard thrice weekly regimen of 3MIU of Roferon-A in cirrhotic patients with chronic hepatitis C. In a subgroup of patients, PEG-IFN pharmacokinetics will be evaluated by repeated blood sampling over the first week after the first injections, monthly during the treatment period, and for 2 weeks after the final injection.

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