IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS

$27,361M01FY2000RRNIH

Scripps Research Institute, La Jolla CA

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Abstract

These studies address the immunobiological basis for viral clearance and viral persistence during hepatitis B and C virus infections. HLA Class I and Class II restricted T cell responses to HBV and HCV antigens are correlated with virological and clinical parameters of liver disease. These studies have led to the development of a synthetic peptide vaccine for the treatment of chronic Hepatitis B. Current studies focus on the virological and immunological basis for viral persistence during chronic Hepatitis C virus infection.

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