INSULIN AND ROSIGLITAZONE IN LH INDUCED OVARIAN RESPONSE

$0M01FY2000RRNIH

University Of California San Diego, La Jolla CA

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Abstract

Determine the role of insulin on LH-induced ovarian responses in polycystic ovary syndrome (PCOS) and normal women. The hypothesis is that in PCOS women excess androgen production results from increased ovarian theca cell sensitivity to LH compared to that of normal women and that this increased sensitivity is facilitated by hyperinsulinemia. Similar studies will look at gonadotoropin secretion and FSH as well as using the drug Metformin.

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