MGI-114 IN CHILDREN WITH SOLID TUMORS

$0M01FY2000RRNIH

University Of California San Diego, La Jolla CA

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Abstract

Determine the maximum tolerated dose, the dose-limiting toxicity, incidence and severity of other toxicities of MGI-114 given IV daily to children with refractory malignancies. Determine the pharmacokinetics of MGI-114, and seek preliminary evidence of anti-tumor activity against recurrent pediatric solid tumors.

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