OLANZAPINE + DEVALPROEX VS PLACEBO + DEVALPROEX

$0M01FY2000RRNIH

University Of California San Diego, La Jolla CA

Investigators

Linked publications & trials

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Abstract

Determine whether a pharmacokinetic or pharmacodynamic drug interaction occurs during the co-administration of divalproex sodium and olanzapine, determine the safety of the co-administered drugs, determine the physiologic disposition of olanazpine in combination with divalproex sodium, assess the effects of single dose and multiple doses of olanzapine on steady-state valproic acid concentrations, and evaluate the neuroendocrine effects of the combined drugs.

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