TREATMENT OF RHEUMATOID ARTHRITIS BY BACTERIAL DNAJ DESENSITIZATION

$0M01FY2000RRNIH

University Of California San Diego, La Jolla CA

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Abstract

Determine if oral administration of dnaJ peptides can diminish hypersensitivity to the antigen and lead to clinical improvement in rheumatoid arthritis. Test the effects of oral peptide administration on mechanisms of T cell recognition and reactivity to bacterial dnaJ and assess the effect of oral peptide administration on clinical measurements of joint inflammation.

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