CUMULATIVE EFFECTS OF GLUCOCORTICOIDS &FOOD ON LEPTIN DIURNAL

$0M01FY2000RRNIH

Columbia University Health Sciences, New York NY

Investigators

Linked publications & trials

Paper 39187183 Paper 35137558 Paper 35108352 Paper 34918583 Paper 33002231 Paper 32826426 Paper 32492148 Paper 31505070 Paper 31404238 Paper 30260099 Paper 30185666 Paper 27460711 Paper 27341145 Paper 27210268 Paper 27077672 Paper 26831192 Paper 26745610 Paper 26518356 Paper 26490495 Paper 26450815 Paper 26344673 Paper 26239175 Paper 26203360 Paper 26069025 Paper 25807066 Paper 25753294 Paper 25616474 Paper 25406899 Paper 25285942 Paper 25130063 Paper 25063755 Paper 24994947 Paper 24721190 Paper 24659368 Paper 24637299 Paper 24573903 Paper 24522445 Paper 24382103 Paper 24244562 Paper 24167085 Paper 24123357 Paper 24093080 Paper 23949428 Paper 23932915 Paper 23889039 Paper 23630307 Paper 23599941 Paper 23593417 Paper 23592658 Paper 23588557 Paper 23555620 Paper 23439301 Paper 23332671 Paper 23322788 Paper 23308020 Paper 23277390 Paper 23243391 Paper 23128762 Paper 23090351 Paper 23086558 Paper 23033246 Paper 22836187 Paper 22774307 Paper 22739582 Paper 22573794 Paper 22545107 Paper 22545032 Paper 22505764 Paper 22491495 Paper 22473767 Paper 22440811 Paper 22383118 Paper 22341881 Paper 22258265 Paper 22182463 Paper 22173789 Paper 22145457 Paper 22130149 Paper 22070283 Paper 22027585 Paper 21999979 Paper 21917907 Paper 21764604 Paper 21704565 Paper 21643551 Paper 21489573 Paper 21406009 Paper 21383843 Paper 21373790 Paper 21311512 Paper 21271789 Paper 21257979 Paper 21205691 Paper 21178607 Paper 21145352 Paper 21070775 Paper 21036173 Paper 20975515 Paper 20937946 Paper 20848585

Abstract

The aim of this experiment is to investigate whether the mechanisms by which glucocorticoids and food intake stimulate leptin in vivo involve change in the leptin diurnal cycle, and whether this effect is different between lean and obese human subjects. To answer this question, the effect of dexamethasone (0 and 2 mg) on 24-hour serum leptin will be studied in lean and obese human subjects under fed and fasting conditions. We hypothesize that: 1) dexamethasone alone, under fasting condition, will increase serum leptin levels at night and induce the nocturnal peak of leptin; 2) the cumulative effect of dexamethasone and food will increase the amplitude of the nocturnal peak of leptin, and interfere with the timing of this peak.

View original record on NIH RePORTER →