SERTRALINE TREATMENT OF MAJOR DEPRESSION AFTER ACUTE MYOCARDIAL INFARCTION

$0M01FY2000RRNIH

Columbia University Health Sciences, New York NY

Investigators

Linked publications & trials

Paper 39187183 Paper 35137558 Paper 35108352 Paper 34918583 Paper 33002231 Paper 32826426 Paper 32492148 Paper 31505070 Paper 31404238 Paper 30260099 Paper 30185666 Paper 27460711 Paper 27341145 Paper 27210268 Paper 27077672 Paper 26831192 Paper 26745610 Paper 26518356 Paper 26490495 Paper 26450815 Paper 26344673 Paper 26239175 Paper 26203360 Paper 26069025 Paper 25807066 Paper 25753294 Paper 25616474 Paper 25406899 Paper 25285942 Paper 25130063 Paper 25063755 Paper 24994947 Paper 24721190 Paper 24659368 Paper 24637299 Paper 24573903 Paper 24522445 Paper 24382103 Paper 24244562 Paper 24167085 Paper 24123357 Paper 24093080 Paper 23949428 Paper 23932915 Paper 23889039 Paper 23630307 Paper 23599941 Paper 23593417 Paper 23592658 Paper 23588557 Paper 23555620 Paper 23439301 Paper 23332671 Paper 23322788 Paper 23308020 Paper 23277390 Paper 23243391 Paper 23128762 Paper 23090351 Paper 23086558 Paper 23033246 Paper 22836187 Paper 22774307 Paper 22739582 Paper 22573794 Paper 22545107 Paper 22545032 Paper 22505764 Paper 22491495 Paper 22473767 Paper 22440811 Paper 22383118 Paper 22341881 Paper 22258265 Paper 22182463 Paper 22173789 Paper 22145457 Paper 22130149 Paper 22070283 Paper 22027585 Paper 21999979 Paper 21917907 Paper 21764604 Paper 21704565 Paper 21643551 Paper 21489573 Paper 21406009 Paper 21383843 Paper 21373790 Paper 21311512 Paper 21271789 Paper 21257979 Paper 21205691 Paper 21178607 Paper 21145352 Paper 21070775 Paper 21036173 Paper 20975515 Paper 20937946 Paper 20848585

Abstract

This study will investigate the safety of sertraline (Zoloft) in patients with recent myocardial infarction who are experiencing an episode of major depression. Many investigations have shown that elevated levels of symptoms of depression are associated with an increased risk of death due to cardiovascular disease. Recently, major depressive disorder occurring in the first few weeks after myocardial infarction (MI) was shown to be associated with a four-fold increase in the risk of death over the subsequent 6-18 months, even after adjustment for other risk factors. Although the efficacy and safety of serotonin reuptake inhibitor antidepressants have been established in trials with over 10,000 patients, patients with unstable coronary artery disease or recent MI have generally been excluded from these studies. This study will be a multi-site randomized double-blind parallel-group study comparing sertraline to placebo treatment in patients with clinically diagnosed depression following acute myocardial infarction.

View original record on NIH RePORTER →