LOCALLY DELIVERED PYRIDOSTIGMINE BROMIDE &COLONIC MOTIL

$0M01FY2000RRNIH

Mayo Clinic Coll Of Medicine, Rochester, Rochester MN

Investigators

Linked publications & trials

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Abstract

Our hypothesis is that a colonic delivery system (CDS) is effective in delivery of pyridostigmine bromide to the colon, thereby accelerating the colonic transit of solid residue. Our specific aims are to evaluate the dose-related effects of pyridostigmine bromide (5, 10, 20 mg) compared to placebo delivered via a colonic delivery system on colonic transit time, particularly on the rate of emptying of the ascending and transverse colon; and to assess the bioavailability of pyridostigmine bromide delivered by means of a colonic delivery system.

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