R108512 AND GI/COLONIC TRANSIT IN FUNCTIONAL CONSTIPATION OR IBS

$0M01FY2000RRNIH

Mayo Clinic Coll Of Medicine, Rochester, Rochester MN

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Abstract

The hypothesis is that R108512 dose dependently accelerates colonic transit in patients with functional constipation or constipation-predominant irritable bowel syndrome. The specific aim of this study is to measure gastric, small bowel, and colonic transit in 40 patients with functional constipation or constipation-predominant irritable bowel syndrome randomized to placebo, 0.5, 2.0, or 4.0 mg per day as a single dose of R108512.

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