NITRIC OXIDE KINETICS ACROSS SKELETAL MUSCLE IN TYPE 1 DIABETES MELLITUS

$0M01FY2000RRNIH

Mayo Clinic Coll Of Medicine, Rochester, Rochester MN

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Abstract

The specific aims of the study include the assessment of the turnover rates across the leg muscle bed of arginine and citrulline in Insulin-deprived Type I diabetics. The local effect of insulin will be seen on NO production using the arginine-citrulline cycle. The effect of insulin on leg vascular tone will also be seen.

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