ROLE OF ESTROGEN DEFICIENCY IN PATHOGENESIS OF IMPAIRED COLLAGEN METABOLISM

$0M01FY2000RRNIH

Mayo Clinic Coll Of Medicine, Rochester, Rochester MN

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Abstract

The purpose of this study is to determine if estrogen deficiency plays a major role in the pathogenesis of the changes in collagent metabolism in postmenopausal women, and whether these changes can be prevented or reversed by estrogen replacement therapy. A new method utilizing stable isotopes for quantifying the dermal synthesis rate of collagen in vivo will be used. We have established the necessary techniques to measure skin collagen synthesis rates using stable isotopes.

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