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EXERCISE REGULATIONS OF LOWER BODY LIPOLYSIS IN HUMANS

$0M01FY2000RRNIH

Mayo Clinic Coll Of Medicine, Rochester, Rochester MN

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Abstract

Our hypothesis is that regional differences in lipolysis are a primary determinant of regional fat distribution in non-obese men and women and in upper-body versus lower-body obesity. The specific aims of the study are to determine whether exercise stimulates lower-body adipose tissue FFA release in men, but not women; non-obese men have greater abdominal adipose tissue meal fatty acid uptake than non-obese women; meal fatty acid uptake and oxidation is different in the follicular versus luteal phase of the menstrual cycle; gender related differences in meal fatty acid oxidation and adipose tissue uptake can be accounted for by differences in body composition; consuming a larger meal specifically increases abdominal subcutaneous adipose tissue meal fatty acid uptake in individuals with an android as opposed to a gynoid fat distribution; and weight loss induced by energy restricted diets results in decreased meal fatty acid oxidation and increased meal fatty acid uptake in subcutaneous adipose tissue.

View original record on NIH RePORTER →