ORAL DOSE OF TYRAMINE IN EARLY PARKINSON'S DISEASE

$0M01FY2000RRNIH

Boston University Medical Campus, Boston MA

Investigators

Linked publications & trials

Paper 39016335 Paper 38574825 Paper 38423369 Paper 37944567 Paper 36990659 Paper 36638096 Paper 36608946 Paper 36515151 Paper 34166677 Paper 33964299 Paper 33713764 Paper 33712279 Paper 33535024 Paper 32997571 Paper 32380068 Paper 32211507 Paper 31975895 Paper 31821220 Paper 31163174 Paper 30807269 Paper 30529451 Paper 30325721 Paper 30079758 Paper 29847987 Paper 29693324 Paper 29518416 Paper 29449165 Paper 29431692 Paper 29203084 Paper 28939248 Paper 28726810 Paper 28089873 Paper 28076879 Paper 28012682 Paper 27696762 Paper 27654103 Paper 27345271 Paper 26882078 Paper 26810768 Paper 26660077 Paper 26621483 Paper 26573086 Paper 26409873 Paper 26335733 Paper 26194603 Paper 26076097 Paper 25991385 Paper 25979524 Paper 25891759 Paper 25794658 Paper 25776953 Paper 25654966 Paper 25642295 Paper 25634646 Paper 25499536 Paper 25407158 Paper 25381429 Paper 25332071 Paper 25207357 Paper 25129677 Paper 25096690 Paper 25089868 Paper 25061054 Paper 25047592 Paper 24999059 Paper 24986785 Paper 24978115 Paper 24908147 Paper 24565455 Paper 24397611 Paper 24313245 Paper 24171497 Paper 24090620 Paper 24075505 Paper 23908447 Paper 23902481 Paper 23871264 Paper 23811475 Paper 23754238 Paper 23740775 Paper 23712984 Paper 23710672 Paper 23595876 Paper 23547217 Paper 23373577 Paper 23277139 Paper 23095764 Paper 23080542 Paper 23014674 Paper 22975753 Paper 22975469 Paper 22877808 Paper 22840687 Paper 22773928 Paper 22713374 Paper 22616219 Paper 22549368 Paper 22512461 Paper 22508400 Paper 22494228

Abstract

The objective of this study is to evaluate the effect of an oral dose of tyramine in subjects treated with rasagiline (1mg or 2mg) or placebo. Rasagiline is a MAO-B inhibitor. Diets high in tyramine could potentially cause side effects such as high blood pressure, palpitations, and headaches. Following a regular meal, subjects will have baseline hemodynamic monitoring, then receive a standard dose of tyramine and then be closely monitored for possible hypertensive reaction. The total duration for each subject will be four to six hours. Only subjects who have completed the double-blind phase of Rasagiline study but have not begun the active treatment phase will be invited to participate in this sub-study.

View original record on NIH RePORTER →