Maternal estriol monitoring for antenatal steroid efficacy

$0M01FY2000RRNIH

La Biomed Res Inst/ Harbor Ucla Med Ctr, Torrance CA

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Abstract

Only half of preterm infants treated with antenatal steroids are affected, i.e. do not develop respiratory distress syndrome. We have devised a method for determining whether the infant has responded before delivery. Additional patients are needed to validate the methodology and to further develop a genetic test based on the original functional assay of estriol. The genetic marker will improve the diagnosis and provide information to develop specific therapies."

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