MUSCLE DYSFUNCTION IN OBSTRUCTIVE LUNG DISEASE

$982M01FY2000RRNIH

La Biomed Res Inst/ Harbor Ucla Med Ctr, Torrance CA

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Abstract

To improve the effectiveness of medical treatment for people with lung disease produced by cigarette smoking. Chronic obstructive pulmonary disease (COPD) is a disabling disorder and inability to exercise is a foremost problem. Focus will be on strategies predicted to improve the muscle's ability to tolerate exercise. Strategies include administering testosterone to COPD patients to increase muscle mass and initiating a conditioning program consisting of a varied group of weight lifting exercises to improve exercise tolerance.

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