MULTI COUNTRY RANDOMIZED, DOUBLE BLIND TRIAL ON EFFECT OF VALSARTAN IN CHF

$982M01FY2000RRNIH

La Biomed Res Inst/ Harbor Ucla Med Ctr, Torrance CA

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Abstract

Congestive heart failure is a complex clinical syndrome often manifested by shortness of breath and fatigue. Because overt heart failure is characterized by activation of the renin-angiotensin system, angiotensin converting enzyme inhibitors are being used in congestive failure. Despite clinical trials showing efficacy of ACE inhibitors, mortality in congestive failure patients is still very high. The current study is designed to assess the utility of Valsartan, an orally active agent that competes with the receptors for angiotensin II, to see if it produces greater inhibition of the renin-angiotensin system and thus improves mortality and morbidity. Patient enrollment will continue in the coming year and previously enrolled patients will be followed for 24-36 months.

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