TREATMENT OF HYPERCALCEMIC/HYPERCALCIURIC PATIENTS W/ CHLOROQUINE,HYD

$982M01FY2000RRNIH

La Biomed Res Inst/ Harbor Ucla Med Ctr, Torrance CA

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Abstract

It is hypothesized that disordered calcium homeostasis in malignant and non-malignant lymphoproliferative disorders may result from the overproduction of active Vitamin D metabolites in immune cells. The ability of the chloroquine derivatives to inhibit extrarenal 1,25-(OH) 2-D production in sarcoidosis, other granuloma-forming states and lymphoma is being assessed. Based upon the patients entered to date, it appears that 1,25-(OH) 2-D levels drop significantly within days of treatment initiation.

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