PATHOGENESIS OF HUMAN PITUITARY ADENOMAS

$982M01FY2000RRNIH

La Biomed Res Inst/ Harbor Ucla Med Ctr, Torrance CA

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Abstract

It is hypothesized that pituitary tumor induction may be related to disorder hypothalamic secretion leading to unrestricted, polyclonal pituitary cell hyperplasia. Alternatively, these tumors may arise from a somatic mutation in a single cell, producing a monoclonal tumor. Pituitary tumor tissue is are acquired for genetic and histmorphologic studies. Thus far, RAS mutations have been found to be uncommon.

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