METABOLIC &IMMUNOGENETIC EVALUATION OF DPT-1 SCREENED RELATIVES: ANTI ISLET AUTO

$0M01FY2000RRNIH

University Of Minnesota Twin Cities, Minneapolis MN

Investigators

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Abstract

Biochemically defined antibodies to pancreatic beta cell antigens will be used to identify subjects who may be susceptable to develop type 1 diabetes mellitus but who are islet cell antibody (ICA) negative. Glucose tolerance tests will be performed in those subjects to assess insulin c-peptide secretion. Subjects who are biochemical antibody positive but ICA negative and who also have antibodies to adrenal gland 21-hydroxylase will have testing for adrenal gland response to ACTH.

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