Minimal effective melatonin dose for circadian entrainment in blind people

$0M01FY2000RRNIH

Oregon Health And Science University, Portland OR

Investigators

Linked publications & trials

Paper 37914632 Paper 33002231 Paper 32603605 Paper 32176647 Paper 31505070 Paper 31404238 Paper 30684471 Paper 30012837 Paper 28236716 Paper 27870939 Paper 27669423 Paper 26957355 Paper 26812281 Paper 26807428 Paper 26416619 Paper 25328912 Paper 25122491 Paper 24911216 Paper 24077434 Paper 23985292 Paper 23891537 Paper 23538569 Paper 23416849 Paper 23208029 Paper 23140884 Paper 23102124 Paper 22669363 Paper 22569476 Paper 22514099 Paper 21803872 Paper 21728433 Paper 21494919 Paper 21466949 Paper 21367394 Paper 21297427 Paper 21234692 Paper 21185275 Paper 21128149 Paper 21035033 Paper 20926574 Paper 20876818 Paper 20803391 Paper 20801706 Paper 20643702 Paper 20630734 Paper 20624243 Paper 20604695 Paper 20522090 Paper 20494414 Paper 20466110 Paper 20430137 Paper 20388787 Paper 20231619 Paper 20227053 Paper 20215591 Paper 20206848 Paper 20201937 Paper 20167187 Paper 20159182 Paper 20143429 Paper 20140523 Paper 20044903 Paper 20031601 Paper 19866475 Paper 19850743 Paper 19838935 Paper 19784398 Paper 19679306 Paper 19631786 Paper 19597134 Paper 19509608 Paper 19506209 Paper 19454588 Paper 19412328 Paper 19360491 Paper 19327589 Paper 19196720 Paper 19171833 Paper 19101685 Paper 19081833 Paper 19037811 Paper 19014790 Paper 18981035 Paper 18660445 Paper 18632003 Paper 18585512 Paper 18525292 Paper 18521501 Paper 18502162 Paper 18450845 Paper 18419322 Paper 18395206 Paper 18334754 Paper 18317425 Paper 18282317 Paper 18272671 Paper 18240245 Paper 18208859 Paper 18206696 Paper 18165936

Abstract

This research study will look at 24-hour (circadian) rhythms that are "free-running." That is, they are not synthesized to the 24-hour day. Circadian rhythms are generated by an area of the brain, sometimes called the "circadian clock." These rhythms include body temperature, sleepiness and the secretion of certain hormones. The circadian clock is ordinarily synchronized to the light-dark cycle; this is probably the reason that free-running (non 24-hour) circadian rhythms occur commonly in people who are totally blind. Our recent studies have shown melatonin's ability to entrain free-running rhythms in blind people to a 24 hour day. The goals of this study are: A) to examine what dose is necessary to prevent circadian rhythm from free-running once it has been entrained with melatonin treatment; and B) to look at the relationship of each individual circadian rhythm to the dose of melatonin necessary to entrain to a 24 hour day.

View original record on NIH RePORTER →