Antiarrhythmic effects of n-3 fatty acids

$0M01FY2000RRNIH

Oregon Health And Science University, Portland OR

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Abstract

The purpose of this proposal is to assess the antiarrhythmic effects of n-3 polyunsaturated fatty acid (n-3 PUFA) dietary supplementation in patients who have survived ventricular tachycardia or fibrillation and have an implantable cardioverter defibrillator (ICD). The demonstration of a significant electrophysiologic and antiarrhythmic effect of an inexpensive and well tolerated dietary supplement in this high risk but relatively small subgroup would be a reason to consider a subsequent larger trial of dietary supplementation with n-3 PUFA for the primary prevention of sudden death in other high-risk populations.

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