3-aminopyridine-2-carbozaldehyde thiosemicarbazone (3AP) in cancer

$0M01FY2000RRNIH

Yale University, New Haven CT

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Abstract

The objective of the first clinical study is to determine the effects of Triapine Injection on patients with solid tumors by evaluating the following: 1) safety and tolerability; 2) maximum tolerated dose (MTD) and recommended dose for Phase II studies; 3) pharmacokinetics; and 4) tumor response.

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