STUDY TO DETERMINE INCREMENTAL ACTIVITY &SAFETY OF ANTIB1 WITH 131 IODINE

$34,535M01FY2000RRNIH

Yale University, New Haven CT

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Abstract

The primary objective of this study is to assess the incremental clinical activity from radiolabeling Anti-B1 with 131 Iodine as compared to unlabeled Anti-B1 inpatients with relapsed low-grade B-cell NHL in a randomized controlled trial. Secondary objective includes comparison of the response rates, duration of overall and complete response, time-to-treatment failure, and safety and tolerance between the unlabeled Anti-B1 arm and the Anti-B1 RIT arm. In additions, these comparisons will be made between the unlabeled Anti-B1 arm and crossover RIT therapy.

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