HPA AXIS FUNCTION AND HIPPOCAMPUS IN WOMEN WITH SEXUAL ABUSE RELATED PTSD

$34,535M01FY2000RRNIH

Yale University, New Haven CT

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Abstract

The purpose of this study is to measure the hypothalamic-pituitary-adrenal axis (HPA) function and the hippocampus in women with Posttraumatic Stress Disorder (PTSH) related to childhood sexual abuse. The study will entail measurement of hippocampal volume with MRI, assessment of memory function with neuropsychological testing, 24 hour measurement of plasma cortisol, ACTH and Beta-endorphin, a CRF and ACTH challenge test and administration of dexamethasone with measurement of memory function.

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