EFFECTS OF FATTY ACIDS ON MUSCLE GLYCOGEN SYNTHESIS

$34,535M01FY2000RRNIH

Yale University, New Haven CT

Investigators

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Abstract

This study is designed to test the hypothesis that fatty-acids inhibit insulin-dependent glucose uptake mainly by a reduction in muscle glycogen systhesis. If there is such a defect in glycogen synthesis, its mechanism will be further investigated, since decreased muscle glycogen synthesis could be due to inhibition glycogen synthase activity or glucose transport/phosphorylation.

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