INTRACELLULAR HOMOCYSTEINE &METHIONINE KINETICS IN HUMANS

$32,930M01FY2000RRNIH

University Of Vermont &St Agric College, Burlington VT

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Abstract

Homocysteine has been established as an independent risk factor in cardiovascular disease, but the reason why some individuals have elevated plasma homocysteine concentrations is not thoroughly understood. Homocysteine is a sulfur containing amino acid that is a metabolic intermediate between the other sulfur containing amino acids,methionine and cysteine. Storch et al. developed a method using stable isotope tracers to evaluate sulfur amino acid kinetics.

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