ISONIAZID AND RIFABUTIN IN HIV RELATED TUBERCULOSIS

$0M01FY2000RRNIH

New York University School Of Medicine, New York NY

Investigators

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Abstract

The primary objective of this substudy of USPHS Study 23 is to determine the proportion of patients with HIV-related tuberculosis who have abnormal pharmacokinetics(PK) of isoniazid and rifabutin. Secondary objectives are to determine the risk factors of abnormal PK; to evaluate the correlation between PK and toxicity of the drugs; and to define and correlate phenotypic INH acetylator status with the results of genotypic acetylator data obtained in the parent trial.

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