CISPLATIN &CARBOPLATIN INDUCED DNA PROTEIN CROSS LINKS IN CANCER PATIENTS

$21,006M01FY2000RRNIH

New York University School Of Medicine, New York NY

Investigators

Linked publications & trials

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Abstract

This is an observational cohort study designed to describe the application of the sodium dodecyl sulfate (K-SDS) assay, used to detect DNA-topoisomerase complexes, to peripheral blood monocytes exposed to cisplatin or carboplatin. DNA-protein crosslinks from patient PBMC prior to and 4h (cisplatin) or 48h (carboplatin) after the first treatment with antineoplastic drugs will be determined.

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