CONTINUOUS INFUSION OF TOPOTECAN + 5 FU &LEUCOVORIN IN ADVANCED MALIGNANCIES

$21,006M01FY2000RRNIH

New York University School Of Medicine, New York NY

Investigators

Linked publications & trials

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Abstract

This Phase I study attempts to establish the maximum tolerated dose and dose limiting toxicity of low dose continuous infusion topotecan in combination with 5-Fluorouracil for advanced malignancies and establish a recommended Phase II dose based on the MTD. Pharmacokinetic and pharmacodynamic studies of topotecan will be done. Anti-tumor activity will be assessed.

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