21 DAY TOPOTECAN INFUSION WITH CISPLATIN IN OVARIAN CANCER

$21,006M01FY2000RRNIH

New York University School Of Medicine, New York NY

Investigators

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Abstract

The primary objective of this Phase II pilot study is to evaluate the combination of 21 day continuous topotecan infusion with cisplatinin with respect to toxicity and tolerance. The intent of this study is to insure the feasibility of this regimen prior to beginning a randomized Phase III study versus taxol and cisplatin. Response rate, time to progression and topoisomerase-I levels in PBMC will be also be monitored. This study has become an ECOG/NYGOG study.

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