TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER

$21,006M01FY2000RRNIH

New York University School Of Medicine, New York NY

Investigators

Linked publications & trials

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Abstract

This Phase I trial will attempt to determine the maximally tolerated dose and pharmacokinetics of a combination of standard dose tamoxifen with 9-cis retinoic acid. Dose-limiting toxicity, response rate, duration of response, and survival will be determined. Levels of the various subtypes of retinoic acid receptors, retinoid X receptor, and retinoid orphan receptor mRNA and protein in tissue derived from the patient's primary and metastatic tumors will be characterized. The Core Laboratory has produced, purified, and titered an adenovirus vector expressing the retinoic acid receptor for preclinical studies relevant to breast cancer. The Core Laboratory was utilized for use of laminar flow hoods and recombinant DNA Techniques.

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