COLCHICINE IN THE TREATMENT OF PULMONARY FIBROSIS

$21,006M01FY2000RRNIH

New York University School Of Medicine, New York NY

Investigators

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Abstract

This study will evaluate inflammatory mediators from patients with pulmonary fibrosis by bronchoalveolar lavage (IL-1 Beta, TNF-alpha, IL-8, fibronectin) and bronchial brushing (fibronectin, TGF-Beta). It will also modulate inflammatory mediators by placing patients on a regime of colchicine daily and follow-up bronchoscopy studies at six and twelve weeks. The ELISA reader was utilized in the Core Laboratory.

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