ANGIOTENSIN RECEPTOR ANTAGONISM WITH CANDESARTAN

$0M01FY2000RRNIH

Vanderbilt University, Nashville TN

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Abstract

AT1 receptor antagonist, candesartan, and the aldosterone antagonist, spironolactone, will interact to decrease PAI-1 synthesis under conditions of activation of the RAAS. SPECIFIC AIM: To test the hypothesis that aldosterone and Ang II increase PAI-1 by comparing the effects of placebo, AT1 receptor blocker candesartan, and the aldosterone receptor antagonist spironolactone on fibrinolytic system in healthy subjects.

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