FREE RADICALS, MEMBRANES AND ENZYME PHOTOACTIVATION

$0M01FY2000RRNIH

Vanderbilt University, Nashville TN

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Abstract

Development of arterial plaque results from oxidation of lipoproteins, particularly low-density lipoproteins. SPECIFIC AIM: The objective of this study is to determine the mechanisms governing the free radical oxidation of lipids and proteins in low-density lipoproteins (LDL). LDL are isolated from fresh human blood and exposed to free redical initiators. Products of LDL oxidation are isolated and the effect of natural and man-made antioxidants are assessed.

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