CCG 09718 PEDIATRIC/INTRAVENOUS DOLASTATIN-10 IN REFRACTORY TUMORS

$0M01FY2000RRNIH

Vanderbilt University, Nashville TN

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Abstract

A dose of dolastatin 10 which is associated w/ acceptable toxicities can be identified in pediatric patients w/recurrent solid tumors. SPECIFIC AIMS: 1) To determine the maximum tolerable dose of dolastatin 10 given by intravenous bolus infusion once every 21 days in pediatric patients w/refractory solid tumors. 2) To determine the toxicities of dolastatin 10 given on this schedule. 3) To determine the pharmacokinetic behavior of dolastatin-10 administered by intravenous blous to pediatric patients. 4) To determine the activity of dolastatin-10 within the confines of a Phase I study.

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