R115777 IN COMBI W/ PACLITAXEL &CARBOPLATIN IN INCURABLE CANCER

$0M01FY2000RRNIH

Vanderbilt University, Nashville TN

Investigators

Linked publications & trials

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Abstract

Phase I trial of a combination of R115777 in combination w/Paclitaxel and Carboplatin in patients w/advanced cancer. Paclitaxel and carboplatin is an active regimen against a number of malignancies, including lung cancer and therefore this regimen is being developed w/the intention of pursuing future phase II and phase III studies. R115777 is a new oral agent that inhibits signal trasduction by blocking farnesylation of the ras protein. Interestingly, R115777 appears to be more active against normal ras than mutated ras, but has been active against all three types of ras proteins. SPECIFIC ENDPOINTS: (1)To determine dose limiting toxicity (DLT) and MTD of chronic oral, q12 hours administration of R115777 in combination w/paclitaxel/carboplatin. (2))To investigate potential pharmacokinetic interactions. (3)To evaluate performance of the FACT-G quality of life instrument in subjects w/advanced cancer. (4)To determine whether an increase in unfarnesylated lamin B1 can be detected in circulating cells obtained from subjects receiving R115777 orally and carboplatin/paclitaxel intravenouly.

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