EFFECT OF PIPERINE ON CYTOCHROME P450 ACTIVITY

$0M01FY2000RRNIH

Vanderbilt University, Nashville TN

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Abstract

That the pungent ingredient of black and long pepers, piperine, modulates the catalytic activity of cytochrome P450, using selective in vivo probes, the effects of acute oral dosing w/piperine, on individual cytochrome P450 (CYP1A, CYP2A6, CYP2C9, CYP2C19,CYP2D6, CYP2E1 and CYP3A) in healthy subjects.

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