EFFECT OF OLTIPRAZ ON CYTOCHROME P450 ACTIVITY

$0M01FY2000RRNIH

Vanderbilt University, Nashville TN

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Abstract

That the cancer chemopreventive agent oltipraz modulates the catalytic activity of cytochrome P450, using selective in vivo probes, the effects of acute oral dosing w/lotipraz on individual cytochrome P450 (CYP) isoforms (CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A) in healthy subjects.

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