EVALUATE INDINAVIR IN CSF IN HIV INFECTED PATIENTS RECEIVING MULTIPLE DOSES

$592M01FY2000RRNIH

Vanderbilt University, Nashville TN

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Abstract

Evaluate the pharmacokinetic properties of indinavir in the CSF of patients with HIV disease. This prospective study will utilize a highly intensive continous CSFsampling technique and will characterize the CSF pharmacokinetics of indinavir in HIB-infected patients receiving indinavir and lamivudine, plus zidovudine or stavudine, and to compare the CST and plasma concentration-time profile of indinavir, including CSF/plasma ratios of pharmacokinetic parameters.

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