Diphosphoglycerate levels &shifts in oxygen dissociation curve in ill children

$0M01FY2000RRNIH

Children'S Hosp Pittsburgh/Upmc Hlth Sys, Pittsburgh PA

Investigators

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Abstract

To investigate whether critically ill children respond to the stress of illness by increasing production of 2,3-DPG levels, promoting a rightward shift of the oxygen dissociation curve and increased liberation of oxygen from hemoglobin for cellular respiration. Is this compensatory response limited to only a specific subset of physiologic stimuli or whether this response is generalized for all critical illness.

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