INFANTILE ESOPHAGITIS--NATURAL HISTORY AND OPTIMAL THERAPY

$0M01FY2000RRNIH

Children'S Hosp Pittsburgh/Upmc Hlth Sys, Pittsburgh PA

Investigators

Linked publications & trials

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Abstract

To determine the optimal diagnostic strategy, and components and duration of therapy of infantile esophagitis. Both retrospective and prospective components. Infants will be randomized to therapy using a 2x2 factorial design a prokinetic, an acid secretion inhibitor, both, or dual placebo. Patients will undergo repeat esophageal biopsies and reflux questionnaires to evaluate objective and subjective response to therapy and stability of healing.

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